SCIENTIFIC References

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1 - Herrschaft H. et al. (2012) – Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomized, placebo-controlled trial confirming that 240 mg daily improves cognition and quality of life in mild-to-moderate dementia. J. Psychiat. Res. 46(6): 716–723.

2 - Tunali-Akbay T. et al. (2007) – Protective effects of Ginkgo biloba extract against mercury(II)-induced oxidative damage in rats, suggesting its potential role in detoxifying heavy metal neurotoxicity. Phytother. Res. 21(1): 26–31.

3 - Tan MS, Yu JT, Tan CC, et al. (2015). Efficacy and adverse effects of Ginkgo biloba for cognitive impairment and dementia: A systematic review and meta-analysis. Journal of Alzheimer's Disease. 43(2):589–603. doi:10.3233/JAD-140837.

4 - Shi C, Liu J, Wu F, Yew DT. (2010). Ginkgo biloba extract in Alzheimer’s disease: From action mechanisms to medical practice. International Journal of Molecular Sciences. 11(1):107–123. doi:10.3390/ijms11010107.

5 - Bacopa Monnieri (Memory, Acetylcholine Production, Mental Clarity) 5. Pase M.P. et al. (2012) – The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J. Altern. Complement. Med. 18(7): 647–652. 6. Peth-Nui T. et al. (2012) – Effects of 12-week Bacopa monnieri consumption on attention, cognitive processing, working memory, and cholinergic functions in healthy elderly volunteers. Evid. Based Complement. Alternat. Med. 2012: 606424. 7. Calabrese C, Gregory WL, Leo M, et al. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine. 14(6):707–713. doi:10.1089/acm.2008.0018. 8. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of Ethnopharmacology. 151(1):528–535. doi:10.1016/j.jep.2013.11.008.

6 - Acetylcholine's Role in Memory Retention & Cognitive Performance 9. Maurer S.V. & Williams C.L. (2017) – Degeneration of central cholinergic neurons impairs memory, enhancement of cholinergic signaling improves cognitive processes. Front. Immunol. 8: 1489. 10. Hampel H, Mesulam MM, Cuello AC, et al. (2018). The cholinergic system in Alzheimer's disease. Brain. 141(7):1917–1933. doi:10.1093/brain/awy132. 11. Ferreira-Vieira TH, Guimaraes IM, Silva FR, Ribeiro FM. (2016). Alzheimer's disease: Targeting the cholinergic system. Current Neuropharmacology. 14(1):101–115. doi:10.2174/1570159x13666150716165726.

7 - Phosphatidylserine (Salmon-derived, Cognitive Decline Mitigation 12. Vakhapova V. et al. (2010) – Phosphatidylserine containing omega-3 fatty acids (PS-DHA) in non-demented elderly with memory complaints: a double-blind, placebo-controlled trial. Dement. Geriatr. Cogn. Disord. 29(5): 467–474. 13. Richter Y, Herzog Y, Lifshitz Y, et al. (2013). Effect of soybean-derived phosphatidylserine on cognitive performance in elderly. Clinical Interventions in Aging. 8:557–563. doi:10.2147/CIA.S40348. 14. Glade MJ, Smith K. (2015). Phosphatidylserine and the human brain. Nutrition. 31(6):781–786. doi:10.1016/j.nut.2014.10.014.

8 - PFAS and Environmental Toxins (Cognitive Health & Memory Impairment) 15. Park S.K. et al. (2021) – PFAS and cognitive function in older adults. Environ. Res. 194: 110690. 16. Power MC, Webster TF, Baccarelli AA, Weisskopf MG. (2013). PFAS exposure and cognitive function among older adults. Environmental Research. 126:109–115. doi:10.1016/j.envres.2013.07.007. 17. Niu J, Liang H, Sun Z, Wang F. (2021). PFAS exposure and neurological outcomes. Environmental Pollution. 279:116898. doi:10.1016/j.envpol.2021.116898.

9 - High Failure Rate of Alzheimer’s and Memory Drugs 18. Cummings JL et al. (2014) – Alzheimer's drug-development pipeline: frequent failures. Alzheimers Res. Ther. 6(4): 37. 19. Mehta D et al. (2017). Why Alzheimer's drug trials keep failing. Expert Opinion on Investigational Drugs. 26(6):735–739. doi:10.1080/13543784.2017.1323868.

10 - Gut-Brain Axis & Memory Improvement (Probiotics & Prebiotics) 20. Akbari E. et al. (2016) – Probiotic supplementation improves cognitive function in Alzheimer's. Front. Aging Neurosci. 8: 256. 21. Marx W et al. (2020). Prebiotics, probiotics, cognitive outcomes: Meta-analysis. Neuroscience & Biobehavioral Reviews. 118:472–484. doi:10.1016/j.neubiorev.2020.08.002.